The city of Lexington, Kentucky is off the beaten path, but definitely worth the trip. It's known for being the horse capitol of the world and there are plenty of opportunities to see them in person with the Kentucky Horse Park and the The Thoroughbred Center nearby.
Visitors can stay at the Hilton Lexington Downtown in a good, centralized spot at 369 W. Vine St. The area has become busy with conventions and the Lexington Convention Center is available from the hotel via a skywalk if the need arises.